Tuttle R J, Shier K J
Radiology. 1979 Feb;130(2):311-5. doi: 10.1148/130.2.311.
The histological nature and angiographic characteristics of two cases of Castleman tumor support the concept that these tumors are hamartomatous. On angiography, both tumors exhibited a dense and homogeneous blush in the later phase. In one, in the mediastinum, hypertrophied branches of the bronchial artery gave rise to multiple irregular vascular spaces within the tumor; in the other, in the retroperitoneum, hypertrophied branches of the lumbar artery gave rise to irregular vascular channels spaced throughout the tumor. Histologically, both lesions contained numerous lymphoid follicles which, in the central portion, contained capillary vessels with thick hyalinized walls and prominent endothelial cells. A pathogenesis of hamartoma formation is suggested based on a disturbance of the normal orderly replacement of somatic cells and tissues.
两例Castleman病的组织学特征和血管造影特点支持这些肿瘤是错构瘤的概念。血管造影显示，两个肿瘤在后期均呈现浓密且均匀的造影剂充盈。其中一例位于纵隔，支气管动脉的增粗分支在肿瘤内形成多个不规则血管间隙；另一例位于腹膜后，腰动脉的增粗分支在肿瘤内形成遍布的不规则血管通道。组织学上，两个病变均含有大量淋巴滤泡，在中央部分，有壁增厚且透明变性的毛细血管以及显著的内皮细胞。基于体细胞和组织正常有序替代的紊乱，提示了错构瘤形成的发病机制。
