Sarin S K, Negi V S, Dewan R, Sasan S, Saraya A
Department of Gastroenterology, G. B. Pant Hospital, Delhi, India.
Hepatology. 1995 Jul;22(1):138-41.
Limited information is available on the prevalence of gallstones in the first-degree relatives of gallstone patients. Three groups of subjects were studied by real-time ultrasound examination: group A, 105 index gallstone patients (male/female; 20:85); group B, 330 first-degree relatives of index patients; group C, matched controls for group A (n = 105) and group B (n = 330) subjects. Dietary, anthropometric, and biochemical investigations were carried out. In 39 of 105 (37%) index cases, one or more additional family members had gallstones (positive-index case). The positive-index cases were younger than the remaining index cases (mean age, 33.1 +/- 14 vs. 44.5 +/- 13.1 years; P < .05). Fifty-one of 330 (15.5%) first-degree relatives had gallstones, nearly four and a half times (95% confidence interval [CI], 2.4 to 8.5) more often than in the matched control population (12 of 330 [3.6%]). Thirty-three of 51 (65%) positive relatives were women; mother (37.3%), sister (17.6%) or daughters (10%) to the index patients. There was no difference in the diet, physical activity, and serum lipid profile between the positive index patients and the remaining gallstone patients and positive relatives and their controls. Our results show that there is a strong familial predisposition for gallstone formation. Female relatives of young gallstone patients should be routinely screened for gallstones.
关于胆结石患者一级亲属中胆结石的患病率，目前可用信息有限。通过实时超声检查对三组受试者进行了研究：A组，105例索引胆结石患者（男/女；20:85）；B组，索引患者的330名一级亲属；C组，A组（n = 105）和B组（n = 330）受试者的匹配对照。进行了饮食、人体测量和生化调查。在105例索引病例中的39例（37%）中，有一名或多名其他家庭成员患有胆结石（索引病例阳性）。索引病例阳性者比其余索引病例年轻（平均年龄，33.1±14岁对44.5±13.1岁；P <.05）。330名一级亲属中有51名（15.5%）患有胆结石，比匹配对照人群（330名中的12名[3.6%]）高出近四倍半（95%置信区间[CI]，2.4至8.5）。51名阳性亲属中有33名（65%）为女性；是索引患者的母亲（37.3%）姐妹（17.6%）或女儿（10%）。索引病例阳性患者与其余胆结石患者以及阳性亲属与其对照之间在饮食、身体活动和血清脂质谱方面没有差异。我们的结果表明，胆结石形成存在强烈的家族易感性。年轻胆结石患者的女性亲属应常规筛查胆结石。
