Hossain G A, Islam S M, Mahmood Saiyeeda, Chakrabarty R K, Akhter Nasima
Senior Medical Officer, CNMU, Bangladesh.
Mymensingh Med J. 2003 Jul;12(2):112-6.
Gallbladder disease is four times as common in women as in men, and pregnancy appears to contribute to the development of gallstones. During pregnancy, most women receive ultrasound scans, which are highly sensitive in detecting gallstones. The study was undertaken to evaluate the prevalence of gallstones among the pregnant woman. The aim was to determine any significant difference in the prevalence of gallstone among the pregnant woman compared to the generalized prevalence of gallstone in our community.
The maternal gallbladder was examined in 1336 consecutive obstetric ultrasound scans performed for medical indications at 3rd trimester of pregnancy. The study was conducted in Centre for Nuclear Medicine and Ultrasond (CNMU) Mymensingh on randomly selected subjects, among those who came here for ultrasound evaluation of pregnancy. 500 control were taken from age group between 20-30 yrs who came here for ultrasound examination of lower abdomen other than pregnancy.
Gallstone were found in total one hundred eight cases. Prevalence of gallstone in pregnant woman was 8.08% (n=108). The age ranges were 20 to 45 yrs with mean age of 28.21 +/- 4.95 (mean +/- SD) yrs. The highest prevalence (12.71%) were seen in 3rd or higher gravida group with mean age of 30.32 +/- 4.74 yrs. Significantly higher cases of gallstone were found in multiparity compared to control population of same age group. CONCLUSIONS. Repeated pregnancy causes increased gallstone formation due to changes in gallbladder kinetics leading to stasis and stone formation.
胆囊疾病在女性中的发病率是男性的四倍，而怀孕似乎会促使胆结石的形成。在怀孕期间，大多数女性会接受超声扫描，超声对检测胆结石非常敏感。本研究旨在评估孕妇中胆结石的患病率。目的是确定孕妇中胆结石的患病率与我们社区胆结石的总体患病率相比是否存在显著差异。
在妊娠晚期因医学指征进行的1336例连续产科超声扫描中检查孕妇的胆囊。该研究在迈门辛核医学与超声中心（CNMU）对随机选择的受试者进行，这些受试者是来此进行妊娠超声评估的。500名对照来自年龄在20至30岁之间、来此进行非妊娠下腹超声检查的人群。
共发现108例胆结石。孕妇中胆结石的患病率为8.08%（n = 108）。年龄范围为20至45岁，平均年龄为28.21 +/- 4.95（平均 +/- 标准差）岁。最高患病率（12.71%）出现在孕3产及以上孕妇组，平均年龄为30.32 +/- 4.74岁。与同年龄组的对照人群相比，经产妇中发现的胆结石病例明显更多。结论：多次怀孕会因胆囊动力学改变导致胆汁淤积和结石形成，从而增加胆结石的形成。
