McConnell J R, Antonson D L, Ong C S, Chu W K, Fox I J, Heffron T G, Langnas A N, Shaw B W
Department of Radiology, University of Nebraska Medical Center, Omaha 68198-1045, USA.
Hepatology. 1995 Jul;22(1):69-74.
Evidence indicates that the accumulation of glutamine in the brain plays an important role in the pathogenesis and severity of the encephalopathy of acute liver failure (ALF). This study uses in vivo proton magnetic resonance spectroscopy (1H MRS) to assess brain glutamine (GLN) in five cases of acute liver failure. The findings are consistent with prior investigations and suggest that the alpha 1H of the GLN molecule can be used for noninvasive spectroscopic quantitation of brain GLN in patients with ALF.
有证据表明，大脑中谷氨酰胺的积累在急性肝衰竭（ALF）脑病的发病机制和严重程度中起重要作用。本研究采用体内质子磁共振波谱（1H MRS）对5例急性肝衰竭患者的脑谷氨酰胺（GLN）进行评估。研究结果与先前的调查一致，表明GLN分子的α 1H可用于对ALF患者的脑GLN进行无创波谱定量分析。
