Gupta R K, Saraswat V A, Poptani H, Dhiman R K, Kohli A, Gujral R B, Naik S R
Department of Radiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Am J Gastroenterol. 1993 May;88(5):670-4.
Magnetic resonance imaging (MRI) and in vivo proton spectroscopic changes in the brain in three patients with fulminant hepatic failure are described. MRI showed cerebral atrophy in two and changes somewhat similar to what have been described in chronic hepatic encephalopathy. MR spectroscopy showed low myoinositol with high glutamine in grade IV coma, which returned to normal as patient showed clinical recovery. We conclude that these techniques will be useful in understanding the complex pathophysiology of fulminant hepatic failure.
本文描述了3例暴发性肝衰竭患者脑部的磁共振成像（MRI）及体内质子波谱变化。MRI显示，2例患者出现脑萎缩，其变化与慢性肝性脑病中所描述的情况有些相似。磁共振波谱显示，在IV级昏迷时肌醇水平低而谷氨酰胺水平高，随着患者临床症状的恢复，这些指标恢复正常。我们得出结论，这些技术将有助于理解暴发性肝衰竭复杂的病理生理学。
