Shi B B, Ishikawa N, Itoh H, Khan A I, Tsuchiya K, Horii Y, Nawa Y
Department of Parasitology, Miyazaki Medical College, Japan.
Int J Parasitol. 1995 Mar;25(3):399-402. doi: 10.1016/0020-7519(94)00100-3.
The goblet cell response was examined in the jejunum of the Syrian golden hamster, Mesocricetus auratus, following infection with an intestinal helminth, Strongyloides venezuelensis. After subcutaneous inoculation with 3000 infective larvae (L3), the number of adult worms in the small intestine remained stable up to day 20 and then decreased. Before infection, the number of goblet cells in the jejunum was about 70/10 villi. The number of goblet cells slowly increased, though not significantly, until day 20 post-infection, and then rapidly increased with an inverse relationship to the worm burden. By day 43, when adult worms were almost completely expelled, the number of goblet cells was about 3-fold higher than that of control animals. Similar vigorous goblet cell hyperplasia has not been reported in Strongyloides spp. infection in other experimental animals. Histochemical study revealed that goblet cells in the jejunum of Syrian golden hamsters, unlike those of other experimental animals, produced and released highly sulfated mucins.
在用肠道蠕虫委内瑞拉类圆线虫感染叙利亚金黄地鼠（Mesocricetus auratus）后，对其空肠中的杯状细胞反应进行了研究。皮下接种3000条感染性幼虫（L3）后，小肠中成虫的数量在第20天前保持稳定，随后减少。感染前，空肠中杯状细胞的数量约为70个/10个绒毛。杯状细胞的数量缓慢增加，虽不显著，但一直持续到感染后第20天，然后迅速增加，与虫负荷呈负相关。到第43天，成虫几乎完全排出时，杯状细胞的数量比对照动物高出约3倍。在其他实验动物的类圆线虫属感染中，尚未报道过类似的强烈杯状细胞增生现象。组织化学研究表明，叙利亚金黄地鼠空肠中的杯状细胞与其他实验动物不同，能产生并释放高度硫酸化的粘蛋白。
