Alderson P O, Bradley E W, Mendenhall K G, Vieras F, Siegel B A, Sloan G E, Rogers C C
Radiology. 1979 Feb;130(2):425-33. doi: 10.1148/130.2.425.
To assess the effects of therapeutic doses of radiation on regional pulmonary function, 28 dogs had serial chest radiographs and quantitative ventilation, perfusion, and aerosol studies at three-, six-, nine-, and twelve-month intervals after hemithorax irradiation with 60-Co-gamma photons or 15-MeV fast neutrons. Findings showed marked reductions in perfusion and aerosol deposition in the irradiated lungs of dogs in the high-dose photon and neutron groups and in the medium-dose neutron group. The effects of large photon and small neutron doses were similar (neutron RBE = 4.5). Radionuclide studies were found to be useful for detecting these alterations.
为评估治疗剂量的辐射对局部肺功能的影响，对28只犬在接受60钴γ光子或15兆电子伏快中子半胸照射后，分别于3个月、6个月、9个月和12个月时进行了系列胸部X光片以及定量通气、灌注和气溶胶研究。结果显示，高剂量光子组、高剂量中子组和中剂量中子组犬的照射肺区灌注和气溶胶沉积显著减少。大剂量光子和小剂量中子的效应相似（中子的相对生物效应=4.5）。发现放射性核素研究有助于检测这些改变。
