小鼠β-葡萄糖醛酸酶诱导的一个调控位点Gur控制信使核糖核酸的活性。
A regulatory locus for mouse beta-glucuronidase induction, Gur, controls messenger RNA activity.
作者信息
Paigen K, Labarca C, Watson G
出版信息
Science. 1979 Feb 9;203(4380):554-6. doi: 10.1126/science.760204.
PMID:760204
Abstract
A regulatory locus in a higher organism has been shown to control a specific messenger RNA activity. The Gur locus in mice regulates the production of kidney beta-glucuronidase messenger RNA activity after induction of the beta-glucuronidase structural gene, Gus, by testosterone. beta-Glucuronidase messenger RNA was assayed by its ability to direct the synthesis of catalytically active murine beta-glucuronidase in Xenopus oocytes.
摘要
已证明高等生物中的一个调控位点可控制特定信使核糖核酸的活性。小鼠中的Gur位点在睾酮诱导β-葡萄糖醛酸酶结构基因Gus后，调节肾脏β-葡萄糖醛酸酶信使核糖核酸的活性。通过其在非洲爪蟾卵母细胞中指导合成具有催化活性的小鼠β-葡萄糖醛酸酶的能力来测定β-葡萄糖醛酸酶信使核糖核酸。
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