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小家鼠中磷酸葡萄糖变位酶-3的连锁以及小鼠与人的三个磷酸葡萄糖变位酶基因座的同源性

Linkage of Pgm-3 in the house mouse and homologies of three phosphoglucomutase loci in mouse and man.

作者信息

Nadeau J H, Kömpf J, Siebert G, Taylor B A

出版信息

Biochem Genet. 1981 Jun;19(5-6):465-74. doi: 10.1007/BF00484619.

DOI:10.1007/BF00484619
PMID:6457599
Abstract

The discovery of a third phosphoglucomutase locus (Pgm-3) in the house mouse is reported. Three alleles are recognized on the basis of differences in electrophoretic mobility and enzymatic activity. Pgm-3A (fast mobility and high activity) is present in inbred strain C57BL/10J and 24 other strains; Pgm-3b (slow mobility and high activity) is present in LP/Pas and six other strains; and Pgm-3c (no detectable activity in any tissue tested) is present in strain DBA/2J and 14 other strains. Seventy-four recombinant inbred strains derived from progenitors that differed at Pgm-3 were used to study genic linkage. Pgm-3 is on chromosome 9 and is linked to Sep-1, d, Mod-1, and Ltw-3. Gene order and recombination frequencies are estimated as d 3.8 +/- 1.8%. Pgm-3 2.3 +/- 1.2% Mod-1. Substrate specificities and cofactor requirements show that mouse Pgm-1 is homologous with human Pgm-2, mouse Pgm-2 with human Pgm-1, and mouse Pgm-3 with human Pgm-3.

摘要

报道了家鼠中第三个磷酸葡萄糖变位酶基因座（Pgm - 3）的发现。根据电泳迁移率和酶活性的差异识别出三个等位基因。Pgm - 3A（迁移速度快且活性高）存在于近交系C57BL/10J和其他24个品系中；Pgm - 3b（迁移速度慢且活性高）存在于LP/Pas和其他六个品系中；Pgm - 3c（在所测试的任何组织中均未检测到活性）存在于DBA/2J品系和其他14个品系中。使用来自在Pgm - 3上存在差异的祖代的74个重组近交系来研究基因连锁。Pgm - 3位于9号染色体上，并且与Sep - 1、d、Mod - 1和Ltw - 3连锁。基因顺序和重组频率估计为：d 3.8±1.8%，Pgm - 3 2.3±1.2% Mod - 1。底物特异性和辅因子需求表明，小鼠Pgm - 1与人Pgm - 2同源，小鼠Pgm - 2与人Pgm - 1同源，小鼠Pgm - 3与人Pgm - 3同源。

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The relative activities attributable to the three phosphoglucomutase loci (PGM1, PGM2, PGM3) in human tissues.人类组织中三个磷酸葡萄糖变位酶基因座（PGM1、PGM2、PGM3）的相对活性。
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A kinetic study of the isozymes determined by the three human phosphoglucomutase loci PGM1, PGM2, and PGM3.对由人类三个磷酸葡萄糖变位酶基因座PGM1、PGM2和PGM3所决定的同工酶的动力学研究。
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On the orientation of the HL-A region and the PGM3 locus in the chromosome.关于HL - A区域和PGM3基因座在染色体中的定位。
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'Secondary' isoenzymes derived from the three PGM loci.源自三个磷酸葡萄糖变位酶基因座的“次要”同工酶。
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