Alberti A, Pontisso P, Chemello L, Fattovich G, Benvegnù L, Belussi F, De Mitri M S
Clinica Medica II, University of Padua, Italy.
J Hepatol. 1995;22(1 Suppl):38-41.
Infections by the hepatitis B or C virus are extremely common causes of acute and chronic liver disease, and coexistence of the two viruses in the same patient is not rare. Evidence has been found that such interaction may play an important role in fulminant hepatitis and in the development of hepatocellular carcinoma in cirrhotic patients. Liver disease activity and prognosis have been reported to be generally more serious in the presence of double infection, although an inverse relationship in the replicative levels of the two agents has been noted, suggesting viral interference, particularly in cases of chronic hepatitis. Thus, the two viruses seem to inhibit each other at the molecular level, while cytopathic effects appear to be enhanced. Further studies are needed to explain the mechanisms of these apparently contrasting effects.
乙型或丙型肝炎病毒感染是急性和慢性肝病极为常见的病因，两种病毒在同一患者体内共存并不罕见。已有证据表明，这种相互作用可能在暴发性肝炎以及肝硬化患者肝细胞癌的发生发展中起重要作用。据报道，双重感染时肝病活动度和预后通常更严重，尽管已注意到两种病原体复制水平呈负相关，提示病毒干扰，尤其是在慢性肝炎病例中。因此，两种病毒似乎在分子水平上相互抑制，而细胞病变效应似乎增强。需要进一步研究来解释这些明显相反效应的机制。
