Yagihashi S, Kudo K, Nishihira M
Tohoku J Exp Med. 1979 Jan;127(1):35-44. doi: 10.1620/tjem.127.35.
The peripheral nerves of alloxan and streptozotocin diabetes rats six months after the induction of diabetes were morphologically investigated. The effect of insulin treatment was also examined. Prominent segmental demyelination and remyelination were observed in both alloxan and streptozotocin diabetes rats by isolated nerve fiber studies. Axonal degeneration and globular swelling were also recognized in some nerve fibers. Transmission electron microscopic findings were characterized by the figures of destructed myelin sheaths and axons. Reduplication and thickening of basal lamina of vasa nervorum were noted in the diabetes rats. Scanning electron microscopy revealed three dimensional architectures of degenerated nerve fibers and rough surface of Schwann cells in the diabetes rats. Insulin treated diabetes rats showed less structural changes of nerve fibers. It was indicated that the peripheral nerve lesions of experimental diabetes rats were caused by metabolic impairment of both axons and Schwann cells. Insulin treatment seemed to be effective on the experimental diabetic neuropathy.
对糖尿病诱导六个月后的四氧嘧啶和链脲佐菌素糖尿病大鼠的外周神经进行了形态学研究。还检查了胰岛素治疗的效果。通过分离神经纤维研究，在四氧嘧啶和链脲佐菌素糖尿病大鼠中均观察到明显的节段性脱髓鞘和髓鞘再生。在一些神经纤维中也发现了轴突变性和球状肿胀。透射电子显微镜检查结果的特征是髓鞘和轴突的破坏图像。糖尿病大鼠的神经血管基底膜出现重复和增厚。扫描电子显微镜显示糖尿病大鼠中退化神经纤维的三维结构和雪旺细胞的粗糙表面。胰岛素治疗的糖尿病大鼠神经纤维的结构变化较少。结果表明，实验性糖尿病大鼠的周围神经病变是由轴突和雪旺细胞的代谢损伤引起的。胰岛素治疗似乎对实验性糖尿病神经病变有效。
