弥漫性间质性纤维化肺炎（DIFP）及其他呼吸系统疾病患者前列腺素F2α主要尿代谢产物的放射免疫分析

Radioimmunoassay of main urinary metabolite of prostaglandin F2alpha in patients with diffuse interstitial fibrosing pneumonitis (DIFP) and other respiratory diseases.

作者信息

Kitamura S, Ishihara Y, Kosaka K

出版信息

Tohoku J Exp Med. 1979 Feb;127(2):177-81. doi: 10.1620/tjem.127.177.

DOI:10.1620/tjem.127.177

Abstract

Radioimmunoassay of 5alpha, 7alpha-dihydroxy-11-keto-tetra-norprosta-1,16-dioic acid, main urinary metabolite of prostaglandin F2alpha (PGF2alpha-MUM), was performed in patients with various respiratory diseases including diffuse interstitial fibrosing pneumonitis (DIFP, fibrosing alveolitis). Twenty-four hr excretion of PGF2alpha-MUM in patients with primary lung cancer, pulmonary fibrosis secondary to collagen diseases and stationary DIFP was normal. On the other hand, 24 hr excretion of PGF2alpha-MUM in patients with carcinomatous pleuritis was high and that in patients with aggravating DIFP was markedly high. There was no correlation between serum LDH levels and 24 hr excretion of PGF2alpha-MUM.

摘要

对前列腺素F2α（PGF2α）的主要尿液代谢产物5α,7α - 二羟基 - 11 - 酮 - 四 - 去甲前列腺素 - 1,16 - 二酸进行放射免疫测定，该测定在包括弥漫性间质性纤维化肺炎（DIFP，纤维化肺泡炎）在内的各种呼吸系统疾病患者中进行。原发性肺癌、胶原病继发的肺纤维化和静止期DIFP患者的PGF2α - MUM 24小时排泄量正常。另一方面，癌性胸膜炎患者的PGF2α - MUM 24小时排泄量较高，而病情加重的DIFP患者的排泄量则显著升高。血清乳酸脱氢酶（LDH）水平与PGF2α - MUM 24小时排泄量之间无相关性。