Tanaka N, Tanabe C, Okumura Y, Murakami K
Strahlentherapie. 1979 Jan;155(1):58-62.
The reoxygenation kinetics of the third generation C3H/He mouse mammary carcinoma has been studied and related to the time for 50% of irradiated tumors to regrow to the initial volume at irradiation (TRT-50) and to changes in tumor cell numbers. The experimental results suggest the following conclusions: (1) Fluctuations in TRT-50 values after two-dose irradiation under aerobic conditions are due to reoxygenation. (2) Since the TRT-50 after a second irradiation under hypoxic conditions remains independent of intervals between two doses for at least 3 days, repopulation and synchronization of surviving cells between irradiations is minimal. (3) A decreased cell number and/or cell loss from irradiated tumors is an important factor in tumor reoxygenation.
对第三代C3H/He小鼠乳腺癌的再氧合动力学进行了研究，并将其与50%受照射肿瘤生长至照射时初始体积所需的时间（TRT-50）以及肿瘤细胞数量的变化相关联。实验结果表明以下结论：（1）在有氧条件下两次照射后TRT-50值的波动是由于再氧合。（2）由于在缺氧条件下第二次照射后的TRT-50至少3天内保持与两次照射间隔无关，照射之间存活细胞的再增殖和同步化程度最低。（3）受照射肿瘤细胞数量减少和/或细胞丢失是肿瘤再氧合的一个重要因素。
