关于胞质溶胶对蛋白质与放射性防护剂巯基乙基胍形成的混合二硫键活性的研究。
Studies of the activity of cytosol on the mixed disulfide bond formed by proteins and radio-protector mercaptoethylguanidine.
作者信息
Horváth M, Holland J
出版信息
Strahlentherapie. 1979 Jan;155(1):63-6.
PMID:760279
Abstract
The cytoplasm of normal and tumorous rat liver cells contains a heat-resistant active compound with reducing ability to break the mixed disulfide bond of albumin-14C-mercaptoethylguanidine. The reducing activity of cytosol is destroyed by 1000 krd 60Co-gamma-ray doses in diluted solution. In vivo supralethal irradiation of rats does not affect the activity of cytosol prepared from liver cells.
摘要
正常大鼠和肿瘤大鼠肝细胞的细胞质中含有一种耐热的活性化合物，该化合物具有还原能力，能够破坏白蛋白-14C-巯基乙基胍的混合二硫键。在稀释溶液中，1000 krd的60Co-γ射线剂量可破坏胞质溶胶的还原活性。对大鼠进行体内超致死剂量照射不会影响从肝细胞制备的胞质溶胶的活性。
Zotero 插件