[N-乙酰-β-D-氨基葡萄糖苷酶]
[N-acetyl-beta-D-glucosaminidase].
作者信息
Furuhata N, Shiba K, Nara N
机构信息
Department of Clinical Laboratory, Faculty of Medicine, Tokyo Medical and Dental University Hospital.
出版信息
Nihon Rinsho. 1995 May;53(5):1267-76.
N-acetyl-beta-D-glucosaminidase (NAG), one of the glycolytic enzymes, is distributed in various tissue cells. Among them, the lysosome in the renal proximal tubular cells contains high amount of NAG. NAG is secreted in urine when kidney is damaged. Urinary NAG, therefore, is used as a marker which can detect the extent of the renal damage. Electrophoresis divides urinary NAG into three isozymes, pre A, A, and B forms. In normal males, the percentages of three isozymes are 12.3 +/- 5.56%, 73.15 +/- 4.77%, and 14.81 +/- 2.90%, respectively. In normal females, they are 12.87 +/- 4.70%, 65.47 +/- 4.61%, and 21.70 +/- 5.03%, respectively. The measurement of urinary NAG isozymes is useful to determine the type and severity of renal disease, especially renal tubular disease.
N - 乙酰 - β - D - 氨基葡萄糖苷酶（NAG）是一种糖酵解酶，分布于各种组织细胞中。其中，肾近端小管细胞中的溶酶体含有大量的NAG。肾脏受损时，NAG会分泌到尿液中。因此，尿NAG被用作检测肾脏损伤程度的标志物。电泳可将尿NAG分为三种同工酶，即前A、A和B型。正常男性中，三种同工酶的百分比分别为12.3±5.56%、73.15±4.77%和14.81±2.90%。正常女性中，它们分别为12.87±4.70%、65.47±4.61%和21.70±5.03%。检测尿NAG同工酶有助于确定肾脏疾病的类型和严重程度，尤其是肾小管疾病。
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