在早期类风湿性关节炎中，IgA-α1抗胰蛋白酶复合物与IgM、IgG和IgA类风湿因子相关吗？

Does IgA-alpha1 antitrypsin complex correlate with IgM, IgG and IgA rheumatoid factor in early rheumatoid arthritis?

作者信息

Lacki J K, Hrycaj P, Klama K, Mackiewicz U, Mackiewicz S H, Muller W

机构信息

Hochrhein Institute for Rheumatism Research and Prevention, Bad Sackingen, Germany.

出版信息

Mater Med Pol. 1994 Jul-Sep;26(3):97-100.

PMID:7603085

Abstract

This study was undertaken to determine whether the rheumatoid factor (RF) isotypes affect the level of IgA-AT complex in early rheumatoid arthritis. IgA-AT complex and IgM, IgG, and IgA RF were evaluated using a double antibody enzyme-linked immunosorbent assay (ELISA) in sera of 83 (61 women and 22 men) patients. The mean level of the complex was higher in RA patients as compared with the control group (0.60 +/- 0.41 U vs 0.19 +/- 0.11 U, p < 0.05). The IgA-AT complex values exceeding the norm were found in 19 of 83 RA cases (23%), mainly in patients non-treated with DMARDs. IgM RF values judged as positive were present in 53 (64%), IgG RF in 55 (66%), and IgA RF in 56 (67%) patients. Higher RF values of IgM and IgG, but not those of IgA class, were found more frequently in patients with elevated IgA-AT levels. A good correlation was established between IgA and IgM RF (r = 0.61, p < 0.01), but not between IgA and IgG, or IgM and IgG RF in the group of patients under study. However, we did not find any significant correlation between isotypes of RF and parameters of the disease activity.

摘要

本研究旨在确定类风湿因子（RF）的同种型是否影响早期类风湿关节炎中IgA-抗胰蛋白酶（IgA-AT）复合物的水平。采用双抗体酶联免疫吸附测定（ELISA）对83例（61例女性和22例男性）患者血清中的IgA-AT复合物以及IgM、IgG和IgA RF进行评估。与对照组相比，类风湿关节炎（RA）患者中复合物的平均水平更高（0.60±0.41 U对0.19±0.11 U，p<0.05）。83例RA病例中有19例（23%）的IgA-AT复合物值超过正常范围，主要见于未接受改善病情抗风湿药（DMARDs）治疗的患者。53例（64%）患者的IgM RF值判定为阳性，55例（66%）患者的IgG RF值为阳性，56例（67%）患者的IgA RF值为阳性。在IgA-AT水平升高的患者中，IgM和IgG的RF值较高，但IgA类的RF值并非如此。在所研究的患者组中，IgA与IgM RF之间建立了良好的相关性（r = 0.61，p<0.01），但IgA与IgG之间或IgM与IgG RF之间未建立相关性。然而，我们未发现RF同种型与疾病活动参数之间存在任何显著相关性。