神经性厌食症患者的类固醇排泄情况。

Steroid excretion in anorexia nervosa patients.

作者信息

Vanluchene E, Aertsens W, Vandekerckhove D V

出版信息

Acta Endocrinol (Copenh). 1979 Jan;90(1):133-8. doi: 10.1530/acta.0.0900133.

DOI:10.1530/acta.0.0900133

Abstract

Seven anorexia nervosa (A.N.) patients had reduced urinary excretion values of tetrahydrocortisone (THE), androsterone (A) and 5alpha-tetrahydrocortisol (5alpha-THF). THE to tetrahydrocortisol (THF), A to aetiocholanolone (Ae) and 5alpha-THF to THF ratios were all significantly reduced. Six A.N. patients had oral metyrapone tests with quantitatively normal but delayed urinary 3alpha,17alpha,21-trihydroxy-5beta-pregnan-20-one (THS) response. The steroid determinations were done by capillary gaschromatography, which proves to be of value in the study of the above mentioned metabolic abnormalities.

摘要

七名神经性厌食症（A.N.）患者的四氢皮质醇（THE）、雄酮（A）和5α-四氢皮质醇（5α-THF）尿排泄值降低。THE与四氢皮质醇（THF）的比值、A与本胆烷醇酮（Ae）的比值以及5α-THF与THF的比值均显著降低。六名A.N.患者进行了口服甲吡酮试验，尿中3α,17α,21-三羟基-5β-孕烷-20-酮（THS）的反应在数量上正常但延迟。类固醇测定采用毛细管气相色谱法，该方法在上述代谢异常的研究中被证明具有价值。