Adachi Y, Mori M, Haraguchi M, Sugimachi K, Tsuneyoshi M
Second Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Pathology. 1995 Jan;27(1):5-7. doi: 10.1080/00313029500169372.
We made a cytophotometric DNA analysis using 21 scirrhous gastric carcinomas (SGC), and compared the results with those of 12 undifferentiated type early gastric carcinomas (EGC) located in the gastric body. Nuclear DNA content of tumor cells was measured in the mucosa of SGC (SGCm), serosa of SGC (SGCs) and mucosa of EGC (EGCm). DNA distribution pattern was high ploid in 18 SGCm (86%), 16 SGCs (71%) and 4 EGCm (33%). Mean DNA content was 4.02c in SGCm, 3.91c in SGCs and 3.26c in EGCm. Percentage of tumor cells with a DNA content over 3c was 77.4% in SGCm, 69.1% in SGCs and 49.5% in EGCm. Statistically significant differences in these 3 factors were present between SGCm and EGCm, but absent between SGCm and SGCs. Furthermore, DNA distribution pattern was not different between the mucosa and serosa in 19 SGC (90%). The results suggest that most scirrhous gastric carcinomas are high ploid in origin and do not change their biologic behaviour throughout the tumor progression.
我们对21例胃硬癌（SGC）进行了细胞光度法DNA分析，并将结果与12例位于胃体的未分化型早期胃癌（EGC）的结果进行了比较。在胃硬癌的黏膜（SGCm）、胃硬癌的浆膜（SGCs）和早期胃癌的黏膜（EGCm）中测量肿瘤细胞的核DNA含量。DNA分布模式在18例SGCm（86%）、16例SGCs（71%）和4例EGCm（33%）中为高倍体。SGCm的平均DNA含量为4.02c，SGCs为3.91c，EGCm为3.26c。DNA含量超过3c的肿瘤细胞百分比在SGCm中为77.4%，在SGCs中为69.1%，在EGCm中为49.5%。这三个因素在SGCm和EGCm之间存在统计学显著差异，但在SGCm和SGCs之间不存在。此外，在19例胃硬癌（90%）中，黏膜和浆膜之间的DNA分布模式没有差异。结果表明，大多数胃硬癌起源于高倍体，并且在肿瘤进展过程中其生物学行为没有改变。
