Tapsall J W, Phillips E A
Department of Microbiology, Prince of Wales Hospital, Randwick, New South Wales.
Pathology. 1995 Jan;27(1):64-6. doi: 10.1080/00313029500169492.
One hundred and thirty seven consecutive isolates of Neisseria gonorrhoeae and a further 36 selected gonococci with either chromosomal (CMRNG) or plasmid mediated (PPNG) resistance to penicillin, all cultured in Sydney in 1993, were found to be sensitive to cefpodoxime, an oral third generation cephalosporin antibiotic (MIC range < 0.001-0.25 mg/L). All isolates were also sensitive to ceftriaxone and spectinomycin. Six gonococci showed high level resistance to tetracycline (TRNG, MIC = 32 mg/L) and 12 had decreased susceptibility to quinolone antibiotics (MIC range 0.06-0.5 mg/L). The MIC50 and MIC90 for both cefpodoxime and ceftriaxone were highest amongst CMRNG and ceftriaxone was 2 to 4 times as active as cefpodoxime weight for weight. Cefpodoxime may be a valuable additional oral agent for the treatment of gonorrhea in Australia. The sensitivity of gonococci to cefpodoxime can probably be inferred from values obtained for ceftriaxone.
1993年在悉尼培养的137株连续分离的淋病奈瑟菌以及另外36株经选择的对青霉素具有染色体介导（CMRNG）或质粒介导（PPNG）耐药性的淋球菌，均被发现对口服第三代头孢菌素抗生素头孢泊肟敏感（MIC范围<0.001 - 0.25mg/L）。所有分离株对头孢曲松和大观霉素也敏感。6株淋球菌对四环素表现出高水平耐药（TRNG，MIC = 32mg/L），12株对喹诺酮类抗生素敏感性降低（MIC范围0.06 - 0.5mg/L）。头孢泊肟和头孢曲松的MIC50和MIC90在CMRNG中最高，且头孢曲松的活性按重量计算是头孢泊肟的2至4倍。头孢泊肟可能是澳大利亚治疗淋病的一种有价值的额外口服药物。淋球菌对头孢泊肟的敏感性可能可以从头孢曲松获得的值推断出来。
