头孢泊肟酯（U-76,252；CS-807）对淋病奈瑟菌的体外活性。
In vitro activity of cefpodoxime proxetil (U-76,252; CS-807) against Neisseria gonorrhoeae.
作者信息
Schaadt R D, Yagi B H, Zurenko G E
机构信息
Infectious Diseases Research, Upjohn Company, Kalamazoo, Michigan 49001.
出版信息
Antimicrob Agents Chemother. 1990 Feb;34(2):371-2. doi: 10.1128/AAC.34.2.371.
Abstract
Cefpodoxime proxetil is an oral cephalosporin antibiotic. The in vitro activities of cefpodoxime (the active metabolite of cefpodoxime proxetil), ceftriaxone, and cefuroxime against both antibiotic-susceptible and antibiotic-resistant clinical isolates of Neisseria gonorrhoeae were determined. Cefpodoxime inhibited all penicillin-susceptible strains and penicillinase-producing strains at less than or equal to 0.015 microgram/ml; chromosomally resistant strains were inhibited by cefpodoxime at less than or equal to 0.125 microgram/ml.
摘要
头孢泊肟酯是一种口服头孢菌素类抗生素。测定了头孢泊肟（头孢泊肟酯的活性代谢产物）、头孢曲松和头孢呋辛对淋病奈瑟菌抗生素敏感和耐药临床分离株的体外活性。头孢泊肟在小于或等于0.015微克/毫升时可抑制所有青霉素敏感菌株和产青霉素酶菌株；头孢泊肟在小于或等于0.125微克/毫升时可抑制染色体耐药菌株。
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