Aberg G, Kopp U
Acta Pharmacol Toxicol (Copenh). 1979 Feb;44(2):95-8. doi: 10.1111/j.1600-0773.1979.tb02301.x.
The antiarrhythmic compound, QX 572, has been shown to increase heart rate both in patients and experimental animals. In anaesthetized cats the positive cardiac chronotropic effects were mainly due to increased sympathetic activity. The present experiments were designed to localize the active sites within the sympathetic nerve system. It was found that QX 572 caused an increased heart rate in response to electrical stimulation of the cardiac sympathetic nerves, but this was not due to effects on the CNS, the sympathetic ganglia or the cardiac adrenergic beta-receptors. It is concluded that QX 572 by some action increased the amount of noradrenaline released from the cardiac sympathetic nerve endings. The mechanism for this effect has not been clarified.
抗心律失常化合物QX 572已被证明在患者和实验动物中均可提高心率。在麻醉猫中，心脏正性变时作用主要归因于交感神经活动增强。本实验旨在确定交感神经系统内的活性位点。结果发现，QX 572可使心脏交感神经受到电刺激时心率增加，但这并非由于对中枢神经系统、交感神经节或心脏肾上腺素β受体的作用。结论是，QX 572通过某种作用增加了心脏交感神经末梢释放去甲肾上腺素的量。这种作用的机制尚未阐明。
