Aberg G, Kopp U, Rydén L
Acta Pharmacol Toxicol (Copenh). 1979 Feb;44(2):91-4. doi: 10.1111/j.1600-0773.1979.tb02300.x.
The haemodynamic effects of the antiarrhythmic compound, QX 572, have been studied in anaesthetized cats. It was found that QX 572 increased the heart rate and decreased the blood pressure of the cats during the infusion of the drug. A slight increase in blood pressure was seen after the infusion was terminated. The same results have been obtained in patients. Experiments on cats pretreated with propranolol or reserpine showed that infusions of QX 572 caused an increase in heart rate by increasing the sympathetic activity in the cats. It is also shown that changes in vagal tone may contribute to the effects of QX 572 on the heart rate.
抗心律失常化合物QX 572对麻醉猫的血流动力学效应已得到研究。结果发现，在输注该药期间，QX 572使猫的心率增加，血压降低。输注终止后可见血压略有升高。在患者身上也得到了相同的结果。对用普萘洛尔或利血平预处理的猫进行的实验表明，输注QX 572通过增加猫的交感神经活动而使心率增加。研究还表明，迷走神经张力的变化可能有助于QX 572对心率产生影响。
