Korsager S, Ostergaard Kristensen H P
Acta Med Scand. 1979;205(1-2):115-7. doi: 10.1111/j.0954-6820.1979.tb06013.x.
Among 1107 patients with asthma or chronic asthmatic bronchitis and 96 with hypothyroidism we found 12 patients with both diseases. Seven of these patients had hypothyroidism induced by iodine-containing expectorants. Five of 209 patients with hyperthyroidism had coexistent asthmatic lung disease, but none of these five had been taking iodine. The severity of asthma is considered in relation to changes in thyroid function following withdrawal of iodine. Three patients had an exacerbation of their asthma, while another three had no change in their asthma when the iodine treatment was discontinued and the euthyroid state subsequently restored. All six patients had a marked improvement of their general wellbeing when the euthyroid state was re-established. It is concluded that treatment with iodine-containing expectorants causing hypothyroidism is unwise and should be withdrawn even when the patients praise the beneficial effect of iodine on the asthma per se.
在1107例哮喘或慢性哮喘性支气管炎患者以及96例甲状腺功能减退患者中，我们发现有12例患者同时患有这两种疾病。其中7例患者的甲状腺功能减退是由含碘祛痰剂引起的。209例甲状腺功能亢进患者中有5例同时患有哮喘性肺部疾病，但这5例患者均未服用碘剂。根据停用碘后甲状腺功能的变化来考虑哮喘的严重程度。3例患者的哮喘病情加重，而另外3例患者在停用碘剂并随后恢复甲状腺功能正常状态时哮喘病情未发生变化。当恢复甲状腺功能正常状态时，所有6例患者的总体健康状况均有明显改善。得出的结论是，使用含碘祛痰剂导致甲状腺功能减退进行治疗是不明智的，即使患者称赞碘对哮喘本身的有益作用，也应停用。
