• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一种1型丝氨酸/苏氨酸激酶受体，可使非洲爪蟾的中胚层背化。

A type 1 serine/threonine kinase receptor that can dorsalize mesoderm in Xenopus.

作者信息

Mahony D, Gurdon J B

机构信息

Wellcome/CRC Institute, Cambridge, United Kingdom.

出版信息

Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6474-8. doi: 10.1073/pnas.92.14.6474.

DOI:10.1073/pnas.92.14.6474
PMID:7604016
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC41540/
Abstract

We have cloned a type I serine/threonine kinase receptor, XTrR-I, from Xenopus. XTrR-I (Xenopus transforming growth factor beta-related receptor type I) is expressed in all regions of embryos throughout early development. Overexpression of this receptor does not affect ectoderm or endoderm but dorsalizes the mesoderm such that muscle appears in ventral mesoderm and notochord appears in lateral mesoderm normally fated to become muscle. In addition, overexpression of XTrR-I in UV-treated embryos is able to cause formation of a partial dorsal axis. These results suggest that XTrR-I encodes a receptor which responds in normal development to a transforming growth factor beta-like ligand so as to promote dorsalization. Its function would therefore be to direct mesodermalized tissue into muscle or notochord.

摘要

我们从非洲爪蟾中克隆了一种I型丝氨酸/苏氨酸激酶受体XTrR-I。XTrR-I（非洲爪蟾转化生长因子β相关I型受体）在胚胎早期发育的所有区域均有表达。该受体的过表达不影响外胚层或内胚层，但会使中胚层背化，从而使肌肉出现在腹侧中胚层，而脊索出现在通常注定会发育成肌肉的外侧中胚层。此外，在经紫外线处理的胚胎中过表达XTrR-I能够导致部分背轴的形成。这些结果表明，XTrR-I编码一种受体，该受体在正常发育过程中对转化生长因子β样配体作出反应，从而促进背化。因此，其功能是将中胚层化组织引导至肌肉或脊索中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3085/41540/e9b8a63c5f97/pnas01490-0271-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3085/41540/e0fd2d0c213e/pnas01490-0269-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3085/41540/18a9c1f714cc/pnas01490-0270-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3085/41540/e42a80c3a166/pnas01490-0270-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3085/41540/ae642c4a1482/pnas01490-0271-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3085/41540/e9b8a63c5f97/pnas01490-0271-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3085/41540/e0fd2d0c213e/pnas01490-0269-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3085/41540/18a9c1f714cc/pnas01490-0270-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3085/41540/e42a80c3a166/pnas01490-0270-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3085/41540/ae642c4a1482/pnas01490-0271-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3085/41540/e9b8a63c5f97/pnas01490-0271-b.jpg

相似文献

1
A type 1 serine/threonine kinase receptor that can dorsalize mesoderm in Xenopus.一种1型丝氨酸/苏氨酸激酶受体，可使非洲爪蟾的中胚层背化。
Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6474-8. doi: 10.1073/pnas.92.14.6474.
2
XTrR-I is a TGFbeta receptor and overexpression of truncated form of the receptor inhibits axis formation and dorsalising activity.XTrR-I是一种转化生长因子β受体，该受体截短形式的过表达会抑制轴的形成和背化活性。
Mech Dev. 1998 Jul;75(1-2):95-105. doi: 10.1016/s0925-4773(98)00092-6.
3
A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo.截短的骨形态发生蛋白受体影响非洲爪蟾早期胚胎的背腹模式形成。
Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10255-9. doi: 10.1073/pnas.91.22.10255.
4
Competition between noggin and bone morphogenetic protein 4 activities may regulate dorsalization during Xenopus development.头蛋白与骨形态发生蛋白4活性之间的竞争可能在非洲爪蟾发育过程中调节背侧化。
Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12141-5. doi: 10.1073/pnas.92.26.12141.
5
Raf-1 kinase is essential for early Xenopus development and mediates the induction of mesoderm by FGF.Raf-1激酶对于非洲爪蟾早期发育至关重要，并介导成纤维细胞生长因子对中胚层的诱导作用。
Cell. 1993 May 7;73(3):571-83. doi: 10.1016/0092-8674(93)90143-e.
6
Xnr4: a Xenopus nodal-related gene expressed in the Spemann organizer.Xnr4：一种在施佩曼组织者中表达的非洲爪蟾Nodal相关基因。
Dev Biol. 1997 Apr 15;184(2):367-72. doi: 10.1006/dbio.1997.8510.
7
The transforming growth factor beta type II receptor can replace the activin type II receptor in inducing mesoderm.
Mol Cell Biol. 1994 Jun;14(6):4280-5. doi: 10.1128/mcb.14.6.4280-4285.1994.
8
A truncated bone morphogenetic protein 4 receptor alters the fate of ventral mesoderm to dorsal mesoderm: roles of animal pole tissue in the development of ventral mesoderm.截短的骨形态发生蛋白4受体改变腹侧中胚层向背侧中胚层的命运：动物极组织在腹侧中胚层发育中的作用。
Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10260-4. doi: 10.1073/pnas.91.22.10260.
9
Synergistic effects of Vg1 and Wnt signals in the specification of dorsal mesoderm and endoderm.Vg1和Wnt信号在背侧中胚层和内胚层特化过程中的协同作用。
Dev Biol. 1996 Nov 25;180(1):22-34. doi: 10.1006/dbio.1996.0281.
10
A Xenopus mRNA related to Drosophila twist is expressed in response to induction in the mesoderm and the neural crest.一种与果蝇的twist相关的非洲爪蟾信使核糖核酸（mRNA）在中胚层和神经嵴诱导时表达。
Cell. 1989 Dec 1;59(5):893-903. doi: 10.1016/0092-8674(89)90612-0.

引用本文的文献

1
The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development.孤儿受体ALK7和激活素受体ALK4在脊椎动物发育过程中通过Nodal蛋白介导信号传导。
Genes Dev. 2001 Aug 1;15(15):2010-22. doi: 10.1101/gad.201801.

本文引用的文献

1
A community effect in muscle development.肌肉发育中的群体效应。
Curr Biol. 1993 Jan;3(1):1-11. doi: 10.1016/0960-9822(93)90139-f.
2
The TGF-beta family and its composite receptors.转化生长因子-β家族及其复合受体。
Trends Cell Biol. 1994 May;4(5):172-8. doi: 10.1016/0962-8924(94)90202-x.
3
Secreted noggin protein mimics the Spemann organizer in dorsalizing Xenopus mesoderm.分泌的头蛋白在使非洲爪蟾中胚层背化过程中模拟了施佩曼组织者。
Nature. 1993 Feb 11;361(6412):547-9. doi: 10.1038/361547a0.
4
Single-cell transplantation determines the time when Xenopus muscle precursor cells acquire a capacity for autonomous differentiation.单细胞移植确定了非洲爪蟾肌肉前体细胞获得自主分化能力的时间。
Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1310-4. doi: 10.1073/pnas.90.4.1310.
5
Processed Vg1 protein is an axial mesoderm inducer in Xenopus.加工后的Vg1蛋白是非洲爪蟾中轴中胚层诱导因子。
Cell. 1993 Aug 13;74(3):433-41. doi: 10.1016/0092-8674(93)80045-g.
6
Retinoic acid selectively promotes the survival and proliferation of neurogenic precursors in cultured neural crest cell populations.视黄酸可选择性地促进培养的神经嵴细胞群体中神经源性前体细胞的存活和增殖。
Dev Biol. 1994 Jan;161(1):243-50. doi: 10.1006/dbio.1994.1024.
7
Two distinct transmembrane serine/threonine kinases from Drosophila melanogaster form an activin receptor complex.来自黑腹果蝇的两种不同的跨膜丝氨酸/苏氨酸激酶形成一种激活素受体复合物。
Mol Cell Biol. 1994 Feb;14(2):944-50. doi: 10.1128/mcb.14.2.944-950.1994.
8
Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor.一种与转化生长因子βⅡ型受体形成异源复合物的转化生长因子βⅠ型受体的克隆。
Cell. 1993 Nov 19;75(4):681-92. doi: 10.1016/0092-8674(93)90489-d.
9
Secretion and mesoderm-inducing activity of the TGF-beta-related domain of Xenopus Vg1.
EMBO J. 1993 Dec;12(12):4471-80. doi: 10.1002/j.1460-2075.1993.tb06136.x.
10
Mesoderm-inducing factors in early vertebrate development.
EMBO J. 1993 Dec;12(12):4463-70. doi: 10.1002/j.1460-2075.1993.tb06135.x.