Menghetti E, Mucedola G, Marulli P, Montaleone M, Cugini P
Istituto di Puericultura, Università La Sapienza, Roma.
Recenti Prog Med. 1995 May;86(5):195-7.
This study investigates 263 full-term clinically healthy newborn babies: subdivided into two groups depending on a positive (113 individuals) or negative (150 subjects) family history for hypertension. The babies were comparable for body weight and statural height and equipartitioned into males and females. The infants underwent a non-invasive, automated monitoring of blood pressure during the first three days of their life, according to protocol in which the systolic and diastolic measurements were performed at 1 min intervals over 15 minutes. The babies of the two groups showed superimposable mean values for systolic and diastolic blood pressure. However, the neonates with a positive familiarity for hypertension showed a higher number of systolic readings above the reference limit of 90 mmHg. The higher incidence of the abnormally-elevated systolic values (> 13%) in babies with a positive familiarity for hypertension was seen to be significant, suggesting that their blood pressure pattern is characterized by a larger variability at least in the systolic component. Such a wider variability may be regarded as a phenotypic expression of the genetic predisposition to hypertension, whose risk can be detected by a short-term monitoring of BP soon after the birth.
本研究调查了263名足月临床健康的新生儿：根据高血压家族史呈阳性（113人）或阴性（150人）分为两组。这些婴儿在体重和身高方面具有可比性，并且男女均分。根据方案，婴儿在出生后的头三天接受无创自动血压监测，该方案要求在15分钟内每隔1分钟进行收缩压和舒张压测量。两组婴儿的收缩压和舒张压平均值相近。然而，有高血压家族史阳性的新生儿收缩压读数高于90 mmHg参考限值的数量更多。有高血压家族史阳性的婴儿中收缩压异常升高（>13%）的发生率较高，这被认为具有显著性，表明他们的血压模式至少在收缩压成分上具有更大的变异性。这种更大的变异性可被视为高血压遗传易感性的表型表达，其风险可通过出生后不久对血压的短期监测来检测。
