Wu H Y, Xia Y M, Chen X S
Institute of Nutrition and Food Hygiene, Beijing.
Sheng Li Ke Xue Jin Zhan. 1995 Jan;26(1):12-6.
Type I 5'-deiodinase is a Se-containing enzyme. If Se is deficient, the deiodinase activity would be inhibited, the level of circulation T4 will be elevated, and the concentration T3 in peripheral tissues will be decreased. Se deficiency will also accelerate the iodine depletion of thyroid and may even exacerbate some detrimental effects of iodine deficiency. Possibly Se deficiency is involved in the occurrence and development of iodine deficient disorders. Keshan disease, with Se deficiency as the major cause, was also observed a change of thyroid hormone metabolism. The change of respiratory enzyme activities in myocardium of Keshan disease is in the way somewhat like that of hypothyroidism caused by iodine deficiency. The metabolic change of thyroid hormone after Se deficiency or iodine deficiency may be related to the occurrence of Keshan disease.
I型5'-脱碘酶是一种含硒酶。如果硒缺乏，脱碘酶活性将受到抑制，循环中T4水平会升高，外周组织中T3浓度会降低。硒缺乏还会加速甲状腺的碘耗竭，甚至可能加剧碘缺乏的一些有害影响。硒缺乏可能参与碘缺乏病的发生和发展。以硒缺乏为主要病因的克山病也观察到甲状腺激素代谢的变化。克山病心肌中呼吸酶活性的变化在某种程度上类似于碘缺乏引起的甲状腺功能减退。硒缺乏或碘缺乏后甲状腺激素的代谢变化可能与克山病的发生有关。
