Lu Z W
Department of Pharmacology, School of Basic Medical Sciences, Beijing Medical University.
Sheng Li Ke Xue Jin Zhan. 1995 Jan;26(1):45-9.
Different kinds of single, multiple, acute or chronic administrations of morphinized animal models were established, with which a series of experiments in both in vivo and in vitro systems as well as molecular levels were pharmacologically designed to investigate the psychoneuroimmunological effects of morphine (Mor) and the immunoprotection of Ganoderma polysaccharides peptide (GPP) in Mor-dependent mice. It was first discovered that both c-myb and c-myc mRNA expression in splenocytes of repetitive Mor-treated mice were detected to be significantly decreased, and that GPP could induce restoration of several immunologic parameters depressed by Mor treatment to or even beyond normal levels. This provides the experimental animal evidence that immune response modifiers such as GPP could be of potential application in controlling abuse of opiates-induced immunodeficiency.
建立了不同类型的吗啡化动物模型，包括单次、多次、急性或慢性给药，在此基础上，从药理学角度设计了一系列体内、体外系统以及分子水平的实验，以研究吗啡（Mor）的心理神经免疫学效应以及灵芝多糖肽（GPP）对吗啡依赖小鼠的免疫保护作用。首次发现，重复给予吗啡处理的小鼠脾细胞中c-myb和c-myc mRNA表达均显著降低，且GPP可使被吗啡处理抑制的多项免疫参数恢复至正常水平甚至超过正常水平。这为免疫反应调节剂如GPP在控制阿片类药物滥用所致免疫缺陷方面的潜在应用提供了实验动物证据。
