[灵芝多糖对衰老小鼠脾细胞DNA聚合酶α活性及免疫功能的影响]
[Effects of Ganoderma polysaccharides on the activity of DNA polymerase alpha of splenocytes and immune function in aged mice].
作者信息
Lei L S, Lin Z B
机构信息
Department of Pharmacology, Beijing Medical University, China.
出版信息
Yao Xue Xue Bao. 1993;28(8):577-82.
The activity of DNA polymerase alpha in splenocytes of 24-month-old mice was about 35.6% lower than that of 3-month-old mice. Aged mice were intraperitoneally administered Ganoderma polysaccharides (GL-B) once a day for 4 days and then the activity of the enzyme was assessed. The results showed that GL-B at doses of 25 and 50 mg/kg-1 enhanced the activity of the enzyme in aged mouse splenocytes by 44.0 and 58.8% respectively. In addition, the mixed lymphocyte response to alloantigen, automatic proliferation and IL-2 production of splenocytes in aged mice declined as compared with that in young adult mice. GL-B (50, 100, 200 micrograms.ml-1) was found to restore those parameters to the levels of that of young mice in vitro.
24 月龄小鼠脾细胞中 DNA 聚合酶α的活性比 3 月龄小鼠低约 35.6%。对老年小鼠每天腹腔注射灵芝多糖（GL-B）一次，持续 4 天，然后评估该酶的活性。结果表明，25 和 50 mg/kg-1 剂量的 GL-B 分别使老年小鼠脾细胞中该酶的活性提高了 44.0%和 58.8%。此外，与年轻成年小鼠相比，老年小鼠脾细胞对同种异体抗原的混合淋巴细胞反应、自发增殖和白细胞介素-2 的产生均有所下降。体外实验发现，GL-B（50、100、200 微克·毫升-1）可使这些参数恢复到年轻小鼠的水平。
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