Alloway J A, Salata M P
Department of Medicine, Malcolm Grow Medical Center, Andrews Air Force Base, MD 20331, USA.
Semin Arthritis Rheum. 1995 Apr;24(5):315-22. doi: 10.1016/s0049-0172(95)80003-4.
Quinidine is a commonly used antiarrhythmic agent that is rarely associated with rheumatologic toxicity. However, quinidine-induced lupus, antinuclear antibody negative lupus-like syndrome, polymyalgia rheumatica-like illness, muscle weakness, and isolated creatine phosphokinase elevation have all been reported. We present one case of quinidine drug-induced lupus and another of a quinidine-induced polymyalgia rheumatica-like illness, and review the English literature for rheumatologic toxicity due to quinidine. Prompt recognition of quinidine associated rheumatologic toxicity is important because discontinuation of the medication leads to rapid resolution of clinical symptoms.
奎尼丁是一种常用的抗心律失常药物，很少与风湿性毒性相关。然而，奎尼丁诱发的狼疮、抗核抗体阴性的狼疮样综合征、风湿性多肌痛样疾病、肌肉无力以及孤立性肌酸磷酸激酶升高均有报道。我们报告了1例奎尼丁药物诱发的狼疮和1例奎尼丁诱发的风湿性多肌痛样疾病，并综述了英文文献中关于奎尼丁所致风湿性毒性的报道。迅速识别奎尼丁相关的风湿性毒性很重要，因为停用该药物可使临床症状迅速缓解。
