Wilson J R, Lampman J
Am Heart J. 1979 Feb;97(2):155-8. doi: 10.1016/0002-8703(79)90349-1.
Eighty patients were assigned randomly either to continuous or to intermittent heparin therapy, with control by the Lee-White Clotting Time (LWCT). Major bleeding complications occurred in 7.5 per cent and minor complications in 18 per cent of the entire group. The incidence of major bleeding complications in the continuous group (5 per cent) did not differ significantly from the incidence in the intermittent group (10 per cent). In contrast, bleeding complications were significantly more frequent in patients with soft-tissue trauma due to such procedures as thoracenteses and cut-downs, vascular damage due to other causes, and LWCTs over 35 minutes for 2 consecutive days. The incidence of bleeding complications appear to be the same in patients receiving intermittent as in those receiving continuous heparin therapy. Thoracenteses, cut-downs, and other forms of soft-tissue injury predispose to bleeding complications while laboratory monitoring with the LWCT may help to reduce bleeding complications.
80名患者被随机分配接受持续或间歇肝素治疗，并通过李氏-怀特凝血时间（LWCT）进行监测。整个组中，严重出血并发症发生率为7.5%，轻微并发症发生率为18%。持续治疗组的严重出血并发症发生率（5%）与间歇治疗组（10%）相比，差异无统计学意义。相比之下，因胸腔穿刺和切开等操作导致软组织创伤、其他原因引起血管损伤以及连续两天LWCT超过35分钟的患者，出血并发症明显更频繁。接受间歇肝素治疗的患者与接受持续肝素治疗的患者出血并发症发生率似乎相同。胸腔穿刺、切开及其他形式的软组织损伤易引发出血并发症，而使用LWCT进行实验室监测可能有助于减少出血并发症。
