Okada H, Capen C C, Rosol T J
Department of Veterinary Pathobiology, Ohio State University, Columbus 43220, USA.
Vet Pathol. 1995 May;32(3):315-7. doi: 10.1177/030098589503200315.
Thyroid and parathyroid glands from normal adult sheep and sheep with vitamin D3-induced hypercalcemia were evaluated immunohistochemically for the presence of parathyroid hormone-related protein (PTHrP) and calcitonin (CT). Thyroid follicular cells, C-cells, and parathyroid chief cells stained moderately to strongly positive for PTHrP in both groups of sheep. C-cells were identified as cells positive for cytoplasmic staining of CT. Staining of C-cells for calcitonin in hypercalcemic sheep was diminished in intensity. The data demonstrated that PTHrP is present in the sheep thyroid and parathyroid glands. PTHrP may function as a local paracrine factor in these organs, but its staining intensity was not affected by the induction of hypercalcemia.
对正常成年绵羊以及维生素D3诱导的高钙血症绵羊的甲状腺和甲状旁腺进行免疫组织化学评估，以检测甲状旁腺激素相关蛋白（PTHrP）和降钙素（CT）的存在情况。在两组绵羊中，甲状腺滤泡细胞、C细胞和甲状旁腺主细胞对PTHrP呈中度至强阳性染色。C细胞被鉴定为CT细胞质染色阳性的细胞。高钙血症绵羊中C细胞降钙素染色强度减弱。数据表明，PTHrP存在于绵羊的甲状腺和甲状旁腺中。PTHrP可能在这些器官中作为局部旁分泌因子发挥作用，但其染色强度不受高钙血症诱导的影响。
