Schmieder R E, Schobel H P
Department of Medicine IV, University Erlangen-Nürnberg, Würnberg, Germany.
Am J Cardiol. 1995 Jul 13;76(2):117A-121A. doi: 10.1016/s0002-9149(05)80032-3.
To date, the published database concerning the impact of therapy on endothelial function in essential hypertension and hypercholesterolemia is small and incomplete. Chronic antihypertensive therapy had not yet been proven to restore endothelial function in patients with essential hypertension. In contrast, chronic lipid-lowering therapy is effective in restoring endothelial function of the coronary and peripheral circulation in patients with hypercholesterolemia. A beneficial effect was already documented after 3 months of therapy with fluvastatin but full restoration may last more than 1 year.
迄今为止，已发表的关于治疗对原发性高血压和高胆固醇血症患者内皮功能影响的数据库规模小且不完整。慢性抗高血压治疗尚未被证明能恢复原发性高血压患者的内皮功能。相比之下，慢性降脂治疗对恢复高胆固醇血症患者冠状动脉和外周循环的内皮功能有效。氟伐他汀治疗3个月后已证明有有益效果，但完全恢复可能需要1年以上。
