Enno A, O'Rourke J L, Howlett C R, Jack A, Dixon M F, Lee A
School of Pathology, University of New South Wales, Sydney, Australia.
Am J Pathol. 1995 Jul;147(1):217-22.
The long-term consequences of helicobacter infection were observed in an established murine model of human helicobacter infection. Stomachs of specific pathogen-free BALB/c mice infected with Helicobacter felis were examined for inflammation with particular reference to lymphoid cell proliferation and lymphoepithelial lesions. There was little evidence of an inflammatory response in animals sacrificed up to 19 months after infection. In contrast, from 22 months, 38% of infected animals had lymphoid follicles, whereas no lymphoid follicles were found in noninfected control animals. Lymphoepithelial lesions were observed in 25% of infected mice compared with none in controls. Immunostaining confirmed the B-cell nature of the lymphoid infiltrate. The morphology of these lesions closely resemble those seen in human gastric MALToma. This animal model would provide an opportunity to study the pathogenesis of lymphoproliferative disease.
在已建立的人幽门螺杆菌感染小鼠模型中观察了幽门螺杆菌感染的长期后果。对感染了猫幽门螺杆菌的无特定病原体BALB/c小鼠的胃进行检查，以观察炎症情况，特别关注淋巴细胞增殖和淋巴上皮病变。在感染后长达19个月处死的动物中，几乎没有炎症反应的证据。相比之下，从22个月起，38%的感染动物有淋巴滤泡，而未感染的对照动物中未发现淋巴滤泡。25%的感染小鼠出现淋巴上皮病变，而对照组未出现。免疫染色证实了淋巴浸润的B细胞性质。这些病变的形态与人类胃黏膜相关淋巴组织淋巴瘤中所见的病变非常相似。这个动物模型将为研究淋巴增殖性疾病的发病机制提供机会。
