Calvert R, Randerson J, Evans P, Cawkwell L, Lewis F, Dixon M F, Jack A, Owen R, Shiach C, Morgan G J
Department of Molecular Haematology, Leeds General Infirmary.
Lancet. 1995 Jan 7;345(8941):26-7. doi: 10.1016/s0140-6736(95)91154-5.
The helicobacter-associated transition from chronic gastritis to MALToma (lymphoma of mucosa-associated lymphoid tissue) may require genetic change in the host. We have studied gastrectomy specimens from twelve cases of primary B-cell gastric lymphoma showing evidence of chronic gastritis and low-grade or high-grade MALToma to look for allele imbalance at microsatellites for six tumour-suppressor genes. We detected allelic imbalance at two of these loci (DCC in three, APC in two). In two DCC cases allele imbalance was seen in the transition from chronic gastritis to low-grade MALToma and in the third between low-grade and high-grade. Allele imbalance between chronic gastritis and low-grade MALToma is not necessarily causal in the transition. Rather, genetic change has occurred in the process of transformation.
幽门螺杆菌相关的从慢性胃炎向黏膜相关淋巴组织淋巴瘤（MALToma）的转变可能需要宿主发生基因改变。我们研究了12例原发性B细胞胃淋巴瘤的胃切除标本，这些标本显示出慢性胃炎以及低级别或高级别MALToma的证据，以寻找6个肿瘤抑制基因微卫星处的等位基因失衡。我们在其中两个位点（三个病例中的DCC基因，两个病例中的APC基因）检测到等位基因失衡。在两个DCC基因病例中，等位基因失衡出现在从慢性胃炎向低级别MALToma的转变过程中，而在第三个病例中则出现在低级别和高级别MALToma之间。慢性胃炎和低级别MALToma之间的等位基因失衡在转变过程中不一定是因果关系。相反，在转化过程中已经发生了基因改变。
