Miguez-Burbano M J, Shor-Posner G, Fletcher M A, Lu Y, Moreno J N, Carcamo C, Page B, Quesada J, Sauberlich H, Baum M K
Department of Epidemiology and Public Health, University of Miami School of Medicine, FL 33101, USA.
Allergy. 1995 Feb;50(2):157-61. doi: 10.1111/j.1398-9995.1995.tb05073.x.
Our recent studies have demonstrated that in early HIV-1 infection, elevation of plasma immunoglobulin E (IgE) levels precedes the decline of CD4 cell count and is influenced by vitamin E status. In order to further investigate the role of IgE elevation in HIV-1 infection, we determined IgE levels in HIV-1-seropositive and -seronegative intravenous drug users (IDUs) (n = 38), in relationship to cellular and humoral immune function, liver enzymes, and vitamin E status. To examine the possible impact of the route of HIV-1 infection on IgE levels, comparisons between the cohorts of the HIV-1-seropositive and -seronegative IDUs and homosexual men (n = 45) were also conducted. All HIV-1-seropositive participants had significantly higher (P = 0.003) IgE levels than the HIV-1-seronegative subjects. The HIV-1-seropositive IDUs, moreover, demonstrated significantly higher (P = 0.01) IgE levels than HIV-1-seropositive homosexual men, despite similar CD4 cell counts. Stepwise regression analysis was used to evaluate the possible variables contributing to the IgE variation. HIV-1 status (P = 0.0009), intravenous drug use (P = 0.014), CD8 cell counts (P = 0.0001), plasma level of vitamin E (P = 0.006), and alcohol intake (P = 0.047) were significant, accounting for 71% of the IgE elevation. These findings suggest that IgE may serve as a sensitive marker to reflect the evolution of HIV-1 disease in individuals from different risk groups.
我们最近的研究表明，在HIV-1早期感染中，血浆免疫球蛋白E（IgE）水平升高先于CD4细胞计数下降，且受维生素E状态影响。为了进一步研究IgE升高在HIV-1感染中的作用，我们测定了HIV-1血清阳性和血清阴性静脉吸毒者（IDU）（n = 38）的IgE水平，并将其与细胞和体液免疫功能、肝酶及维生素E状态相关联。为了检验HIV-1感染途径对IgE水平的可能影响，我们还对HIV-1血清阳性和血清阴性IDU队列与同性恋男性队列（n = 45）进行了比较。所有HIV-1血清阳性参与者的IgE水平均显著高于（P = 0.003）HIV-1血清阴性受试者。此外，尽管CD4细胞计数相似，但HIV-1血清阳性IDU的IgE水平显著高于（P = 0.01）HIV-1血清阳性同性恋男性。采用逐步回归分析来评估可能导致IgE变化的变量。HIV-1状态（P = 0.0009）、静脉吸毒（P = 0.014）、CD8细胞计数（P = 0.0001）、血浆维生素E水平（P = 0.006）和酒精摄入量（P = 0.047）均具有显著性，可解释71%的IgE升高。这些发现表明，IgE可能作为一个敏感标志物来反映不同风险群体个体中HIV-1疾病的进展。
