Molecular and cellular biology research in periodontal regeneration and its clinical implication.

The mechanisms by which new periodontium is established on root surfaces previously exposed by periodontal disease have been an area of active research interest. Recently, histological examination of periodontal regeneration has revealed a complex process orchestrated by temporo-spatial specific cell-matrix interactions. Advances in cell and molecular biology techniques have provided invaluable tools to investigate the cascade of events occurring during periodontal regeneration. This paper will provide an overview of current understanding of the cellular and molecular aspects of periodontal repair and regeneration and its implication in applied research resulting in clinical application.