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先天性脊髓内神经母细胞瘤。

Congenital intraspinal neuroblastoma.

作者信息

Hrabovsky E, Jones B

出版信息

Am J Dis Child. 1979 Jan;133(1):73-5. doi: 10.1001/archpedi.1979.02130010079015.

DOI:10.1001/archpedi.1979.02130010079015
PMID:760517
Abstract

Congenital neuroblastoma is a well-recognized entity with a very favorable prognosis for tumor cure. However, a newborn with neurologic deficit owing to intraspinal extension of this tumor is very unusual. Eleven such cases in the world literature are reviewed, and an additional case of a new born with paralysis and a neurogenic bladder at birth is presented in detail. The prognosis for tumor cure is excellent regardless of the mode of therapy used. Because of this fact, treatment should include safe surgical decompression and chemotherapy only. The outlook for the return of normal neurologic function is poor.

摘要

先天性神经母细胞瘤是一种公认的疾病实体,其肿瘤治愈预后非常良好。然而,因该肿瘤脊髓内扩展导致神经功能缺损的新生儿非常罕见。本文回顾了世界文献中的11例此类病例,并详细介绍了另外1例出生时即伴有瘫痪和神经源性膀胱的新生儿病例。无论采用何种治疗方式,肿瘤治愈的预后都非常好。基于这一事实,治疗应仅包括安全的手术减压和化疗。神经功能恢复正常的前景不佳。

相似文献

1
Congenital intraspinal neuroblastoma.先天性脊髓内神经母细胞瘤。
Am J Dis Child. 1979 Jan;133(1):73-5. doi: 10.1001/archpedi.1979.02130010079015.
2
Prognosis for children with neuroblastoma presenting with paralysis.
J Pediatr Surg. 1977 Jun;12(3):419-25. doi: 10.1016/0022-3468(77)90020-3.
3
A case of congenital intraspinal neuroblastoma.
J Pediatr Surg. 1997 Sep;32(9):1371-6. doi: 10.1016/s0022-3468(97)90326-2.
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Neuroblastoma presenting with symptoms of epidural compression at birth: a case report.出生时表现为硬膜外压迫症状的神经母细胞瘤:一例报告
Ital J Pediatr. 2016 May 21;42(1):52. doi: 10.1186/s13052-016-0263-6.
5
[Congenital intraspinal neuroblastomas. A propos of 7 cases treated surgically].
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Congenital dumbbell neuroblastoma.
Spine (Phila Pa 1976). 1995 Jun 1;20(11):1295-300. doi: 10.1097/00007632-199506000-00019.
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Chemotherapy as a therapeutic option for congenital neuroblastoma complicated by paraplegia.化疗作为先天性神经母细胞瘤合并截瘫的一种治疗选择。
Klin Padiatr. 2008 May-Jun;220(3):175-7. doi: 10.1055/s-2008-1065340.
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Congenital neuroblastoma presenting with paraplegia.表现为截瘫的先天性神经母细胞瘤。
Arch Dis Child. 1991 Oct;66(10):1246-7. doi: 10.1136/adc.66.10.1246.
9
Congenital intraspinal neuroblastoma with intraspinal calcification in the neonatal period: report of a case with a 32-year follow-up.新生儿期先天性脊髓内神经母细胞瘤伴脊髓内钙化:1例32年随访报告
Pediatr Radiol. 1983;13(6):335-8. doi: 10.1007/BF01625961.
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The treatment of neuroblastoma with intraspinal extension with chemotherapy followed by surgical removal of residual disease. A prospective study of 42 patients--results of the NBL 90 Study of the French Society of Pediatric Oncology.采用化疗治疗伴有椎管内扩展的神经母细胞瘤,随后手术切除残留病灶。一项针对42例患者的前瞻性研究——法国儿科肿瘤学会NBL 90研究结果
Cancer. 1996 Jul 15;78(2):311-9. doi: 10.1002/(SICI)1097-0142(19960715)78:2<311::AID-CNCR19>3.0.CO;2-Z.

引用本文的文献

1
Neuroblastoma presenting with symptoms of epidural compression at birth: a case report.出生时表现为硬膜外压迫症状的神经母细胞瘤:一例报告
Ital J Pediatr. 2016 May 21;42(1):52. doi: 10.1186/s13052-016-0263-6.
2
Congenital intraspinal neuroblastoma with intraspinal calcification in the neonatal period: report of a case with a 32-year follow-up.新生儿期先天性脊髓内神经母细胞瘤伴脊髓内钙化:1例32年随访报告
Pediatr Radiol. 1983;13(6):335-8. doi: 10.1007/BF01625961.