Osterman J D, Trauner D A, Reznik V M, Lemire J
Department of Neurosciences, University of California School of Medicine, San Diego, USA.
Pediatr Neurol. 1993 Nov-Dec;9(6):482-4. doi: 10.1016/0887-8994(93)90030-g.
OKT3 therapy for prevention or reversal of allograft rejection has been associated with a constellation of acute systemic side effects, defined as an OKT3 first-dose reaction. Specific neurologic syndromes, including aseptic meningitis and diffuse encephalitis, have also been observed. This report describes a 12-year-old girl with steroid-resistant renal allograft rejection who developed hemiparesis associated with initiation of OKT3 therapy.
用于预防或逆转同种异体移植排斥反应的OKT3治疗与一系列急性全身副作用相关,这些副作用被定义为OKT3首剂反应。还观察到了特定的神经系统综合征,包括无菌性脑膜炎和弥漫性脑炎。本报告描述了一名12岁患有类固醇抵抗性肾移植排斥反应的女孩,她在开始OKT3治疗后出现了偏瘫。