Burrows A M, Mooney M P, Smith T D, Losken H W, Siegel M I
Department of Anthropology, University of Pittsburgh, PA 15260, USA.
Cleft Palate Craniofac J. 1995 May;32(3):235-46. doi: 10.1597/1545-1569_1995_032_0235_gotcvi_2.3.co_2.
Craniofacial growth data from craniosynostotic children have shown that suture immobilization results in predictable restrictions of cranial vault growth in a direction perpendicular to the affected suture and compensatory growth at sutures perpendicular to the affected one. This study tests these predictions by using rabbits with nonsyndromic congenital coronal suture synostosis. Data were collected from 96 rabbits divided into three groups: 42 unaffected litter mate controls, 33 partially synostosed rabbits, and 21 completely synostosed rabbits. Markers were placed bilaterally on either side of the vault sutures at 1.5 weeks of age. Serial radiographs were taken at 1.5, 6, 12, and 18 weeks of age for assessment of growth at the vault sutures and of various cranial landmarks. Results revealed that completely synostosed animals had significantly (p < .05) shorter cranial vaults, reduced growth at the coronal suture, and increased growth at the sagittal, frontal, and squamosal sutures compared with unaffected rabbits. Results also showed that the calvarial growth observed in this craniosynostotic rabbit model closely reflects predicted compensatory patterns seen in human clinical populations and that this rabbit model is valuable for understanding the pathogeneses and craniofacial growth patterns of humans with premature cranial suture synostosis.
来自颅缝早闭儿童的颅面生长数据表明，缝合固定会导致颅穹窿在垂直于受影响缝合线的方向上出现可预测的生长受限，并在垂直于受影响缝合线的其他缝合线处出现代偿性生长。本研究通过使用患有非综合征性先天性冠状缝早闭的兔子来验证这些预测。从96只兔子收集数据，这些兔子分为三组：42只未受影响的同窝对照兔、33只部分融合的兔子和21只完全融合的兔子。在1.5周龄时在颅穹窿缝合线两侧双侧放置标记物。在1.5、6、12和18周龄时拍摄系列X光片，以评估颅穹窿缝合线和各种颅骨标志的生长情况。结果显示，与未受影响的兔子相比，完全融合的动物颅穹窿明显更短（p < 0.05），冠状缝生长减少，矢状缝、额缝和鳞状缝生长增加。结果还表明，在这种颅缝早闭兔模型中观察到的颅骨生长密切反映了人类临床群体中预测的代偿模式，并且这种兔模型对于理解人类过早颅缝早闭的发病机制和颅面生长模式具有重要价值。
