Tschakert H, Matern-Pinzek R, Schaffeldt J
Klinik für Radiologische Diagnostik und Nuklearmedizin des Knappschaftskrankenhauses Bardenberg, Akademisches Lehrkrankenhaus der RWTH Aachen.
Aktuelle Radiol. 1995 May;5(3):152-6.
In a double blind clinical study, 50 patients with healthy kidneys were tested for the discharge of renal marker proteins before and after receiving a high or low osmoloar contrast medium (Meglium-Ioglicinat, Imeprol) using i.v. urography. The renal excretion of the tubular indicator enzymes alanine aminopeptidase, beta-Glutamyltranspeptidase and alkaline phosphatase increased in all patients after administration of the contrast media. The enzymuria was significantly lower with the non-ionic contrast medium with the ionic one, thus demonstrating that the non-ionic contrast medium has a lower nephrotoxic potential than the conventional ionic contrast medium. Three independent investigators evaluated the radiograms with regard to the contrast quality using prearranged criteria in a 5 point system. The diversity of the evaluations clearly favoured the non-ionic contrast medium.
在一项双盲临床研究中，对50名肾功能正常的患者在静脉肾盂造影术前和术后使用高渗或低渗造影剂（Meglium-Ioglicinat、Imeprol）检测肾标志物蛋白的排出情况。给予造影剂后，所有患者肾小管指标酶丙氨酸氨基肽酶、β-谷氨酰转肽酶和碱性磷酸酶的肾排泄均增加。非离子型造影剂的酶尿明显低于离子型造影剂，从而表明非离子型造影剂的肾毒性潜力低于传统离子型造影剂。三名独立研究人员使用预先安排的标准，在一个5分制系统中对造影质量方面的X光片进行评估。评估的差异明显有利于非离子型造影剂。
