Pauer H D, Bunge H J
Anaesthesist. 1979 Jan;28(1):39-43.
The reasons for the especial importance of acute lung failure within the framework of intensive medicine are elaborated. In most cases acute lung failure can be successfully treated by timely ventilation and support for the heart-function. If conventional therapy fails, extracorporeal long-term oxygenation by means of a membrane oxygenator can be a successful technique, provided that a very critical indication is available. The magnitude of the intrapulmonary right-left shunt S is an important parameter for the assessment of the extent of acute lung failure and its prognosis, and also in the establishment of the indication for the use of extracorporeal oxygenation and the therapeutic process. The derivation of simple extended shunt equations for any form of extracorporeal oxygenation is possible on the basis of measurements of blood-flow and oxygen transport. This represents an important contribution to the mathematical description of a therapeutic technique.
阐述了急性肺衰竭在重症医学范畴内尤为重要的原因。在大多数情况下，急性肺衰竭可通过及时通气和支持心脏功能得到成功治疗。如果传统治疗失败，在具备非常严格的适应症时，借助膜式氧合器进行体外长期氧合可能是一种成功的技术。肺内右向左分流S的大小是评估急性肺衰竭程度及其预后的重要参数，在确定体外氧合的使用适应症和治疗过程中也很重要。基于血流和氧输送的测量结果，可以推导出适用于任何形式体外氧合的简单扩展分流方程。这对一种治疗技术的数学描述做出了重要贡献。
