胚胎移植日期与人类体外受精-胚胎移植结局的关系

Relationship between the day of embryo transfer and the outcome in human in vitro fertilization and embryo transfer.

作者信息

Goto Y, Kanzaki H, Nakayama T, Takabatake K, Himeno T, Mori T, Noda Y

机构信息

Department of Gynecology and Obstetrics, Kyoto University Faculty of Medicine, Japan.

出版信息

J Assist Reprod Genet. 1994 Sep;11(8):401-4. doi: 10.1007/BF02211726.

DOI:10.1007/BF02211726

PMID:7606152

Abstract

PURPOSE

To clarify the optimal date of embryo transfer (ET), we retrospectively analyzed the relationship between the day of ET and the outcome in human in vitro fertilization and embryo transfer (IVF-ET).

METHOD

Of a total of 307 human IVF-ET cycles performed at Kyoto University Hospital between January 1990 and March 1994, we focused on 207 cases of IVF-ET cycles in which two or three good-quality embryos were transferred. These 207 IVF-ET cycles consisted of 54 Day 2 ET cycles, 79 Day 3 ET cycles, 46 Day 4 ET cycles, and 28 Day 5 ET cycles. We compared the pregnancy and live-birth (plus ongoing pregnancy) rates among these four ET groups.

RESULTS

The pregnancy rates of ET on Days 2 to 4 were not significantly different, whereas Day 5 ET produced a significantly lower pregnancy rate (Day 2, 29.6%; Day 3, 32.9%; Day 4, 30.4%; Day 5, 10.7%). Similar results were obtained for the live-birth (plus ongoing pregnancy) rates (Day 2, 20.3%; Day 3, 18.9%; Day 4, 17.9%; Day 5, 7.1%).

CONCLUSIONS

These results suggest that the day of ET does not fundamentally affect the pregnancy rate in human IVF-ET provided that transfer is made before Day 5.

摘要

目的

为明确胚胎移植（ET）的最佳日期，我们回顾性分析了人类体外受精与胚胎移植（IVF-ET）中ET日期与结局之间的关系。

方法

在1990年1月至1994年3月期间于京都大学医院进行的总共307个人类IVF-ET周期中，我们聚焦于207个IVF-ET周期，这些周期中移植了2个或3个优质胚胎。这207个IVF-ET周期包括54个第2天ET周期、79个第3天ET周期、46个第4天ET周期和28个第5天ET周期。我们比较了这四个ET组之间的妊娠率和活产（加持续妊娠）率。