Schwartz M, Lerman C, Daly M, Audrain J, Masny A, Griffith K
Population Science Division, Fox Chase Cancer Center, Cheltenham, PA 19102, USA.
Cancer Epidemiol Biomarkers Prev. 1995 Apr-May;4(3):269-73.
Our objective was to identify demographic, medical, and psychological correlates of ovarian cancer screening utilization in a sample of women at increased risk. We designed a cross-sectional study that evaluated demographic factors, risk factors, psychological factors, and utilization of ovarian cancer screening in first-degree relatives of ovarian cancer patients. In multivariable analysis, use of CA-125 was associated with number of affected relatives [odds ratio (OR), 2.9; 95% confidence interval (95% CI), 1.3-6.5] and ovarian cancer worries (OR, 2.9; 95% CI, 1.1-8.1). For ultrasound (transvaginal or abdominal), the model included employment status (OR, 2.7; 95% CI, 1.1-6.8) and ovarian cancer worries (OR, 3.3; 95% CI, 1.2-9.1). Significant interaction terms in the ultrasound models indicated that employment was a significant predictor of ultrasound utilization in women with 2 or more affected relatives. Among women with only one affected relative, ultrasound use was strongly associated with the presence of ovarian cancer worries. Utilization of ovarian cancer screening among women at increased risk is influenced by psychological and sociodemographic factors, in addition to level of risk.
我们的目标是在高风险女性样本中确定卵巢癌筛查利用情况的人口统计学、医学和心理相关因素。我们设计了一项横断面研究，评估卵巢癌患者一级亲属的人口统计学因素、风险因素、心理因素以及卵巢癌筛查的利用情况。在多变量分析中，CA-125的使用与受影响亲属的数量[比值比（OR），2.9；95%置信区间（95%CI），1.3 - 6.5]和卵巢癌担忧（OR，2.9；95%CI，1.1 - 8.1）相关。对于超声检查（经阴道或腹部），模型纳入了就业状况（OR，2.7；95%CI，1.1 - 6.8）和卵巢癌担忧（OR，3.3；95%CI，1.2 - 9.1）。超声模型中的显著交互项表明，就业是有2个或更多受影响亲属的女性超声检查利用情况的重要预测因素。在只有1个受影响亲属的女性中，超声检查的使用与存在卵巢癌担忧密切相关。除了风险水平外，高风险女性的卵巢癌筛查利用情况还受到心理和社会人口学因素的影响。
