Kinsley C H, Morse A C, Zoumas C, Corl S, Billack B
Department of Psychology, University of Richmond, VA 23173, USA.
Brain Res Bull. 1995;37(1):103-7. doi: 10.1016/0361-9230(94)00263-0.
Systemic morphine exposure disrupts both maternal behavior (MB) and postpartum aggression, possibly through alterations of olfactory preferences [29]. In the current studies, adult female rats were timed mated and implanted with a unilateral cannula in the lateral ventricle. On day 5 or 6 of lactation, the females were infused with either morphine (2.0 micrograms) or saline (5 microliters) (Experiment 1); or, they were infused with 2.0 micrograms morphine and saline or morphine plus 0.5 micrograms naloxone (Experiment 2). One hour later, they were exposed to bedding soiled by pups, or to clean bedding. The amount of time spent investigating the two bedding types was compared. Morphine produced an aversion to the odor of pups, relative to the saline condition, wherein the females expressed a preference for the odor of pups. Naloxone reversed the effect of the morphine, restoring the preference for pup odors in the females. Thus, morphine disruption of MB may be due to central action on olfactory sensory mechanisms.
全身性吗啡暴露可能通过改变嗅觉偏好，干扰母性行为（MB）和产后攻击行为[29]。在当前研究中，成年雌性大鼠定时交配并在侧脑室植入单侧套管。在哺乳期第5天或第6天，给雌性大鼠注射吗啡（2.0微克）或生理盐水（5微升）（实验1）；或者，给它们注射2.0微克吗啡以及生理盐水或吗啡加0.5微克纳洛酮（实验2）。一小时后，让它们接触被幼崽弄脏的垫料或干净垫料。比较探究这两种垫料类型所花费的时间。与生理盐水组相比，吗啡使雌性大鼠对幼崽气味产生厌恶，而在生理盐水组中，雌性大鼠表现出对幼崽气味的偏好。纳洛酮逆转了吗啡的作用，恢复了雌性大鼠对幼崽气味的偏好。因此，吗啡对母性行为的干扰可能是由于其对嗅觉感觉机制的中枢作用。
