Sithisarn Thitinart, Legan Sandra J, Westgate Philip M, Wilson Melinda, Wellmann Kristen, Bada Henrietta S, Barron Susan
Division of Neonatology, Department of Pediatrics, College of Medicine, University of Kentucky, Lexington, KY, United States.
Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY, United States.
Front Pediatr. 2017 Aug 25;5:180. doi: 10.3389/fped.2017.00180. eCollection 2017.
Opiate addiction is now a major public health problem. Perinatal insults and exposure to opiates such as morphine are well known to affect development of the hypothalamic-pituitary-adrenal axis of the offspring adversely and are associated with a higher risk of developing neurobehavioral problems. Oxycodone is now one of the most frequently abused pain killers during pregnancy; however, limited data are available regarding whether and how perinatal oxycodone exposure (POE) alters neurobehavioral outcomes of the offspring. We demonstrated that exposure to 0.5 mg/kg/day oxycodone was associated with hyperactivity in adult rats in an open field. No significant effects of POE were detected on isolation-induced ultrasonic vocalizations in the early postnatal period or on learning and memory in the water maze in adult offspring. Our findings are consistent with hyperactivity problems identified in children exposed to opiates .
阿片类药物成瘾如今是一个重大的公共卫生问题。围产期损伤以及接触吗啡等阿片类药物会对后代下丘脑 - 垂体 - 肾上腺轴的发育产生不利影响，并且与出现神经行为问题的较高风险相关。羟考酮现在是孕期最常被滥用的止痛药之一；然而，关于围产期羟考酮暴露（POE）是否以及如何改变后代的神经行为结果，现有数据有限。我们证明，成年大鼠每天暴露于0.5毫克/千克的羟考酮会在旷场实验中表现出多动。在出生后早期，未检测到POE对隔离诱导的超声波发声有显著影响，在成年后代的水迷宫实验中也未检测到对学习和记忆的显著影响。我们的研究结果与暴露于阿片类药物的儿童中发现的多动问题一致。
