Eyanson S, Greist M C, Brandt K D, Skinner B
Arch Dermatol. 1979 Jan;115(1):54-6. doi: 10.1001/archderm.115.1.54.
Systemic lupus erythematosus (SLE) developed in as 23-year-old woman with psoriasis during treatment with psoralen-ultraviolet-A (PUVA). The connective tissue disease was characterized by an erythematous rash, hair loss, nephritis, splenomegaly, seizures, and coma. Serum antinuclear antibodies were present in high titer, and hypocomplementemia developed. Antibodies to native or ultraviolet-irradiated DNA were not demonstrated. While the association of psoriasis and lupus may have been fortuitous, the temporal relationships suggest that PUVA treatment in this case may have been of pathogenetic importance in the development of the connective tissue disease.
一名23岁患银屑病的女性在接受补骨脂素-紫外线A（PUVA）治疗期间发生了系统性红斑狼疮（SLE）。这种结缔组织病的特征为红斑皮疹、脱发、肾炎、脾肿大、癫痫发作和昏迷。血清抗核抗体呈高滴度存在，并出现了补体血症。未检测到针对天然或紫外线照射DNA的抗体。虽然银屑病和狼疮的关联可能是偶然的，但时间关系表明，该病例中的PUVA治疗可能在结缔组织病的发生中具有致病重要性。
