Hitman G A
Medical Unit, Royal London Hospital, Whitechapel, UK.
Eye (Lond). 1993;7 ( Pt 2):209-13. doi: 10.1038/eye.1993.50.
Insulin-dependent (type 1) diabetes mellitus (IDDM) is a multifactorial disease with a strong genetic component. The majority of the genetic component can be explained by associations between IDDM and genes in the major histocompatibility complex (MHC). The best single marker for IDDM is based on amino acid polymorphism of the HLA-DQ gene. Current evidence, however, indicates that the MHC susceptibility to IDDM is determined by a combination of HLA class I, II and III genes contained on HLA haplotypes. A non-MHC genetic component to IDDM also exists. To date, the most consistent association is between IDDM and markers of the insulin gene locus.
胰岛素依赖型（1型）糖尿病（IDDM）是一种具有强大遗传成分的多因素疾病。大部分遗传成分可通过IDDM与主要组织相容性复合体（MHC）中的基因之间的关联来解释。IDDM的最佳单一标志物基于HLA-DQ基因的氨基酸多态性。然而，目前的证据表明，MHC对IDDM的易感性由HLA单倍型上包含的HLA I类、II类和III类基因的组合决定。IDDM也存在非MHC遗传成分。迄今为止，最一致的关联是IDDM与胰岛素基因座的标志物之间的关联。
