[Interrelationship between structural variants of the apolipoprotein B and ischemic heart disease and plasma lipid levels].

Xba I and EcoR I polymorphism of the apolipoprotein B (APOB) gene was studied by PCR. A significant increase in the frequency of allele X+ and haplotype H+E+ was demonstrated in patients with coronarographically documented coronary heart disease (CHD) over that of the general population. Association of allele E- with increased levels of serum triglycerides was found. The results provide evidence about the contribution of structural variants of the APOB gene to determining CHD.