[Interrelationship between structural variants of the apolipoprotein B and ischemic heart disease and plasma lipid levels].
作者信息
Stepanov V A, Puzyrev V P, Lemza S V, Karpov R S, Fedorov A Iu
出版信息
Genetika. 1995 Mar;31(3):405-9.
PMID:7607429
Abstract
Xba I and EcoR I polymorphism of the apolipoprotein B (APOB) gene was studied by PCR. A significant increase in the frequency of allele X+ and haplotype H+E+ was demonstrated in patients with coronarographically documented coronary heart disease (CHD) over that of the general population. Association of allele E- with increased levels of serum triglycerides was found. The results provide evidence about the contribution of structural variants of the APOB gene to determining CHD.
摘要
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