Poliakov A P, Telkov M V, Nikiforov A N, Solov'eva N P, Koshechkin V A, Zhukova I M, Surguchev A P
Mol Gen Mikrobiol Virusol. 1990 Oct(10):15-8.
Using the RELP analysis we studied the frequency of X2 allele of apoB gene in three groups of patients: 1) men at the age of 20-59 with lipid metabolism disorders revealed in population inspection of Oktyabrsky district in Moscow; 2) men with ischaemic heart disease and 3) healthy men. It was established that in individuals suffering from type IIa hyperlipidemia the frequency of X2 allele was significantly higher than in healthy donors from Moscow population. Homozygotes for X2 allele of XbaI RELP had 7-9% higher serum cholesterol levels, than homozygotes for X1 allele. The study suggests the X2 allele of the apoB gene to be associated with the development of high plasma cholesterol level. No significant difference in X2 allele frequencies was found between patients with ischaemic heart disease and healthy donors. There was also no association found between cholesterol and triglyceride levels and the presence of X2 allele in this group of patients.
我们运用限制性片段长度多态性（RELP）分析，研究了三组患者载脂蛋白B（apoB）基因X2等位基因的频率：1）在莫斯科十月区人群检查中发现患有脂质代谢紊乱的20至59岁男性；2）患有缺血性心脏病的男性；3）健康男性。结果表明，在患有IIa型高脂血症的个体中，X2等位基因的频率显著高于莫斯科人群中的健康供体。XbaI RELP的X2等位基因纯合子的血清胆固醇水平比X1等位基因纯合子高7 - 9%。该研究表明，apoB基因的X2等位基因与高血浆胆固醇水平的发展有关。在缺血性心脏病患者和健康供体之间未发现X2等位基因频率的显著差异。在这组患者中，也未发现胆固醇和甘油三酯水平与X2等位基因的存在之间存在关联。
