Kümel G, Turley H, Brendel M
Institut für Mikrobiologie (Virusforschung) der Universtät Frankfurt am Main.
Fortschr Med. 1995 May 30;113(15):235-8.
The massive widespread use of a substance to treat HSV could lead to the spread of resistant HSV strains and hence to a failure of treatment in a vital indication. In Germany, three defined substances suitable for treating HSV are available over the counter: Zinc sulfate, heparin and acyclovir. Experiments show that heparin retains its activity even after 20 passages whereas acyclovir produces a completely resistant virus after only a single passage. The inactivation of free HSV by zinc sulfate is reduced after serial passages. However, this partial resistance disappears again spontaneously and may be considered clinically irrelevant. With respect to drug efficacy and resistance, therefore, a combination of zinc sulfate and heparin would appear superior to zinc sulfate alone. The use of the genotoxic DNA polymerase inhibitor acyclovir should be restricted to severe cases of HSV.
大量广泛使用某种物质治疗单纯疱疹病毒（HSV）可能导致耐药HSV毒株的传播，从而导致在重要适应症的治疗中失败。在德国，有三种明确适合治疗HSV的物质可在柜台购买：硫酸锌、肝素和阿昔洛韦。实验表明，肝素即使经过20次传代仍保持其活性，而阿昔洛韦仅经过一次传代就会产生完全耐药的病毒。连续传代后，硫酸锌对游离HSV的灭活作用降低。然而，这种部分耐药性会再次自发消失，在临床上可能被认为无关紧要。因此，就药物疗效和耐药性而言，硫酸锌和肝素联合使用似乎优于单独使用硫酸锌。具有基因毒性的DNA聚合酶抑制剂阿昔洛韦的使用应仅限于HSV的严重病例。
